Advancing Adolescent Tobacco Cessation Intervention Research (R01 Clinical Trial Required) | RFA CA 22 043

Opportunity Information: Apply for RFA CA 22 043

Advancing Adolescent Tobacco Cessation Intervention Research (R01 Clinical Trial Required) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number RFA-CA-22-043) designed to move the field forward on helping adolescents stop using tobacco. The program focuses specifically on developing, testing, implementing, and evaluating behavioral tobacco cessation interventions for youth in the mid- to late-adolescent period, roughly ages 14 through 20. The emphasis on this window reflects the fact that it is a high-risk developmental stage when tobacco use patterns can become more entrenched, making timely, well-designed cessation strategies especially important.

The FOA supports research that is intervention-oriented and behavioral in nature, and it explicitly requires a clinical trial, meaning applicants should be proposing studies that prospectively assign human participants to one or more interventions to evaluate effects on health-related biomedical or behavioral outcomes. In practical terms, the announcement is looking for rigorous intervention research that does more than describe the problem: it should generate evidence about what actually helps adolescents quit, under what conditions, and how those approaches can be delivered in real-world settings. Projects can span the full pipeline from early intervention development through efficacy/effectiveness testing and, importantly, implementation and evaluation, signaling interest not only in whether an intervention can work, but whether it can be adopted, delivered well, and sustained in settings where adolescents can realistically be reached.

The funding mechanism is an NIH R01 research project grant, which typically supports multi-year, investigator-initiated research with clearly defined aims, a strong scientific premise, and a robust plan for recruitment, intervention delivery, outcomes measurement, and analysis appropriate for a clinical trial. The opportunity lists an award ceiling of $3,150,000, indicating the maximum total amount expected per award under this announcement (with actual budgets depending on the scope and allowable costs). The CFDA numbers associated with the opportunity are 93.279 and 93.393, and the activity areas are health and education, consistent with cessation interventions that often involve both clinical/public health outcomes and school or community delivery contexts.

Eligibility is broad and includes many types of U.S. governmental entities and organizations, such as state, county, city or township governments; special district governments; and independent school districts. Public and state-controlled institutions of higher education and private institutions of higher education are eligible, as are federally recognized Native American tribal governments, public housing authorities/Indian housing authorities, and Native American tribal organizations that are not federally recognized tribal governments. The FOA also allows nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions in those categories), for-profit organizations other than small businesses, and small businesses. In addition, the announcement explicitly calls out other eligible applicants that NIH wants to encourage, including Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; tribal governments other than federally recognized; and even non-domestic (non-U.S.) entities (foreign organizations), expanding the range of institutions that can lead or participate in this work.

Key administrative details include the sponsoring agency (NIH), the original posting date (Creation Date: 2022-10-03), and the original application due date (Original Closing Date: 2023-10-16). The listing notes “Expected Awards:” but does not provide a number in the source data provided, which usually means the number of awards may depend on the availability of funds and the merit of applications received.

Overall, this FOA is aimed at strengthening the evidence base for adolescent tobacco cessation by funding clinical trial-driven behavioral intervention research targeted to 14- to 20-year-olds, with attention not only to developing and testing interventions but also to the practical realities of implementing and evaluating them in the settings and systems that serve adolescents.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Advancing Adolescent Tobacco Cessation Intervention Research (R01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279, 93.393.
• This funding opportunity was created on 2022-10-03.
• Applicants must submit their applications by 2023-10-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $3,150,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 22 043

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