Opportunity Information: Apply for HT942526PRCRPCTA

The FY26 Peer Reviewed Cancer Research Program (PRCRP) Clinical Trial Award (CTA) from the Department of the Army (USAMRAA) is a discretionary grant opportunity designed to move cancer research quickly into the clinic. The program is focused on the rapid implementation of clinical trials that could meaningfully improve how cancer is treated or managed, as long as the proposed work fits within at least one of the FY26 PRCRP Topic Areas. In practical terms, this award is meant for projects that are ready to test an intervention in people and have a clear potential to change clinical practice, patient outcomes, or standards of care if successful.

A defining requirement of this funding mechanism is that the application must include a clinical trial. The program allows a wide range of trial stages, from early, exploratory studies such as pilot trials, first-in-human work, or phase 0 efforts that generate key feasibility and biological effect data, all the way through larger, more definitive trials up to phase III that test efficacy in the intended patient population. The types of interventions supported are broad and can include new or repurposed pharmacologic agents (drugs or biologics), medical devices, clinical guidance or care pathways, and newer approaches or technologies that may improve diagnosis, treatment delivery, monitoring, or overall management of cancer.

The solicitation also places strong emphasis on regulatory readiness when it applies. If the proposed clinical trial requires an Investigational New Drug (IND) application, an Investigational Device Exemption (IDE), or an equivalent regulatory submission, that regulatory application must already be submitted to the appropriate agency by the CTA application submission deadline. Importantly, the submission needs to match the specific product (or device) and the specific cancer indication being tested in the proposed trial, signaling that applicants should be well beyond the concept stage and positioned to start the trial without long regulatory delays.

Another distinctive feature is the required inclusion of patient advocates as part of the application. This reflects an expectation that patient perspectives will be integrated into the design and conduct of the trial, such as ensuring the research questions are meaningful to patients, the protocol is feasible and considerate of participant burden, recruitment and retention plans are realistic, and outcomes include measures that matter to people living with cancer.

This award does not support animal studies. Any preclinical development, including animal efficacy or toxicology work needed to justify human testing, must be completed before the award start date. As a result, this mechanism is best suited to teams that have already generated the necessary preclinical or translational evidence and are ready to execute a human clinical trial promptly.

Key administrative details include the opportunity number HT942526PRCRPCTA and a closing date of October 5, 2026. The funding instrument is a grant under the science and technology/research and development category (CFDA 12.420). Eligibility is listed as unrestricted, and the program anticipates making about 10 awards. The award ceiling is not specified in the provided listing, so applicants would need to consult the full announcement or agency guidance for budget limits and any cost-related constraints.

  • The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoW Peer Reviewed Cancer, Clinical Trial Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on 2026-05-06.
  • Applicants must submit their applications by 2026-10-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 10 candidate(s).
  • Eligible applicants include: Unrestricted.
Apply for HT942526PRCRPCTA

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FY26 PRCRP Clinical Trial Award (CTA) - Frequently Asked Questions (FAQs)

1) What is the FY26 PRCRP Clinical Trial Award (CTA)?

The FY26 Peer Reviewed Cancer Research Program (PRCRP) Clinical Trial Award (CTA) is a discretionary grant opportunity from the Department of the Army (USAMRAA) intended to move promising cancer research quickly into the clinic. It supports the rapid implementation of clinical trials that could meaningfully improve how cancer is treated or managed, as long as the project fits within at least one FY26 PRCRP Topic Area.

2) Who is the funding agency for this opportunity?

The funding agency is the Department of the Army, administered through USAMRAA (U.S. Army Medical Research Acquisition Activity).

3) What is the opportunity number?

The opportunity number is HT942526PRCRPCTA.

4) What is the application closing date?

The closing date listed is October 5, 2026.

5) What type of funding instrument is this?

This opportunity uses a grant funding instrument under the science and technology / research and development category.

6) What is the CFDA number associated with this program?

The CFDA number provided is 12.420.

7) What kinds of projects are a good fit for this award?

This award is designed for projects that are ready to test an intervention in people (i.e., in a clinical trial) and that have clear potential to change clinical practice, patient outcomes, or standards of care if successful. The proposed work must align with at least one FY26 PRCRP Topic Area.

8) Is a clinical trial required to apply?

Yes. A defining requirement is that the application must include a clinical trial.

9) What phases or stages of clinical trials does the CTA support?

The CTA supports a wide range of trial stages, from early exploratory studies (such as pilot trials, first-in-human work, or phase 0 efforts) through larger, more definitive trials up to phase III that test efficacy in the intended patient population.

10) What types of interventions can be tested in the supported clinical trials?

Supported interventions are broad and can include new or repurposed pharmacologic agents (drugs or biologics), medical devices, clinical guidance or care pathways, and newer approaches or technologies that may improve diagnosis, treatment delivery, monitoring, or overall management of cancer.

11) Does the proposed project have to match specific PRCRP Topic Areas?

Yes. The program requires that the proposed work fits within at least one of the FY26 PRCRP Topic Areas.

12) What does the program mean by an emphasis on "rapid implementation"?

Based on the description, the intent is to fund clinical trials that can start without long delays and are positioned to produce clinically meaningful evidence, rather than projects still in concept development or extended preclinical build-out.

13) Are regulatory submissions (IND/IDE) required before applying?

If the proposed clinical trial requires an Investigational New Drug (IND) application, an Investigational Device Exemption (IDE), or an equivalent regulatory submission, then that regulatory application must already be submitted to the appropriate agency by the CTA application submission deadline.

14) Does the IND/IDE submission need to match the proposed trial exactly?

Yes. The submission needs to match the specific product (or device) and the specific cancer indication being tested in the proposed trial.

15) What does the regulatory readiness requirement imply for applicants?

It implies applicants should be well beyond the concept stage and positioned to start the trial without long regulatory delays, because the relevant IND/IDE (or equivalent) must already be submitted by the application deadline when required.

16) Are patient advocates required for this award?

Yes. The solicitation requires inclusion of patient advocates as part of the application.

17) Why are patient advocates required, based on the opportunity description?

The requirement reflects an expectation that patient perspectives will be integrated into trial design and conduct. Examples mentioned include making sure the research questions are meaningful to patients, the protocol is feasible and considerate of participant burden, recruitment and retention plans are realistic, and outcomes include measures that matter to people living with cancer.

18) Are animal studies allowed under this award?

No. This award does not support animal studies.

19) Can preclinical development be included as part of the funded work?

No. Any preclinical development, including animal efficacy or toxicology work needed to justify human testing, must be completed before the award start date.

20) What kind of research team is best positioned for this award?

This mechanism is best suited to teams that have already generated the necessary preclinical or translational evidence and are ready to execute a human clinical trial promptly.

21) What is the stated eligibility for applicants?

Eligibility is listed as unrestricted.

22) How many awards does the program expect to make?

The program anticipates making about 10 awards.

23) What is the maximum award amount (award ceiling)?

The award ceiling is not specified in the provided listing. Applicants would need to consult the full announcement or agency guidance for budget limits and any cost-related constraints.

24) What is the overall goal of the CTA mechanism?

The overall goal is to move cancer research quickly into the clinic by funding clinical trials that could meaningfully improve cancer treatment or management and that have the potential to influence clinical practice, patient outcomes, or standards of care if successful.

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