Opportunity Information: Apply for PA 25 125
The NICHD Small Research Grant Program (R03 Clinical Trial Required) is a National Institutes of Health (NIH) funding opportunity from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) designed to support small, focused clinical trials that align with the NICHD mission. In practical terms, it is meant for investigators who have a well-defined clinical trial question that can be answered with a modest budget and a limited project scope, rather than a large multi-site effort. Because this specific announcement is "clinical trial required," the proposed research must include a clinical trial as defined by NIH, meaning the study prospectively assigns human participants to an intervention (which could include behavioral, educational, preventive, diagnostic, or therapeutic strategies, depending on the context) in order to evaluate effects on health-related biomedical or behavioral outcomes.
This opportunity is categorized as a discretionary grant mechanism and uses the NIH R03 activity code, which is commonly used for pilot studies, feasibility work, early-stage testing of an intervention, or other tightly scoped projects that can generate preliminary evidence and inform larger studies later. The listed award ceiling is $50,000, signaling that this program is intended for smaller budgets compared with larger NIH clinical trial mechanisms. The funding activity category is Health, Income Security and Social Services, and it is associated with CFDA number 93.865, which corresponds to NICHD-related assistance listings.
Eligibility is broad and includes many types of applicant organizations. Public-sector applicants may include state, county, and city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Higher education institutions are eligible across the spectrum, including public and state-controlled institutions of higher education as well as private institutions of higher education. Tribal entities are explicitly included, both federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized governments, and the opportunity also highlights additional eligible groups such as Tribally Controlled Colleges and Universities (TCCUs), Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI). The announcement also allows participation from faith-based or community-based organizations, eligible federal agencies, regional organizations, and applicants located in a U.S. territory or possession. Nonprofit organizations are eligible whether or not they have 501(c)(3) status, and for-profit organizations (including small businesses and other for-profit entities that are not small businesses) are also listed as eligible. Notably, non-domestic (non-U.S.) entities (foreign organizations) are included as eligible applicants, which can be important for clinical trial questions requiring international settings or populations, provided the work fits NICHD priorities and complies with NIH policies.
From a timing standpoint, the opportunity was created on 2024-11-18, and the original closing date is listed as 2028-01-07, indicating a multi-year open period typical of NIH program announcements with recurring submission cycles. While the summary data provided does not specify the number of expected awards, the long open window suggests ongoing opportunities for submission across multiple receipt dates. Overall, the program can be read as a targeted route for teams that have a clinical trial concept within NICHDs scientific scope and need a smaller grant to test an approach, establish feasibility, collect early efficacy signals, or otherwise generate the clinical trial evidence base needed to justify a subsequent, larger-scale study.Apply for PA 25 125
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "NICHD Small Research Grant Program (R03 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2024-11-18.
- Applicants must submit their applications by 2028-01-07.
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NICHD Small Research Grant Program (R03 Clinical Trial Required)
What is the NICHD Small Research Grant Program (R03 Clinical Trial Required)?
It is a National Institutes of Health (NIH) funding opportunity from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) that supports small, focused clinical trials aligned with the NICHD mission. It is intended for projects with a well-defined clinical trial question and a modest, limited scope (not large multi-site efforts).
Which NIH institute sponsors this opportunity?
The sponsoring institute is the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health (NIH).
What does "R03" mean in this funding opportunity?
R03 is an NIH activity code commonly used for small research grants. In practice, it is often used for pilot studies, feasibility work, early-stage testing of an intervention, or other tightly scoped projects that can produce preliminary evidence and inform larger future studies.
Is a clinical trial required under this announcement?
Yes. This specific announcement is "clinical trial required," meaning the proposed research must include a clinical trial as defined by NIH.
How does NIH define a clinical trial for this opportunity?
The study must prospectively assign human participants to an intervention in order to evaluate effects on health-related biomedical or behavioral outcomes.
What counts as an "intervention" in the required clinical trial?
Interventions can include behavioral, educational, preventive, diagnostic, or therapeutic strategies, depending on the context, as long as participants are prospectively assigned and outcomes are evaluated.
What types of projects is this opportunity best suited for?
It is designed for small, focused clinical trials with a limited project scope and modest budget, such as feasibility studies, pilot testing, or early signals of efficacy that can support a later, larger study.
What is the award ceiling for this program?
The listed award ceiling is $50,000, signaling that this program is intended for smaller budgets compared with larger NIH clinical trial mechanisms.
Is this a discretionary grant mechanism?
Yes. The opportunity is categorized as a discretionary grant mechanism.
What is the funding activity category associated with this opportunity?
The funding activity category is Health, Income Security and Social Services.
What CFDA number is associated with this opportunity?
It is associated with CFDA 93.865, which corresponds to NICHD-related assistance listings.
Who is eligible to apply?
Eligibility is broad and includes many organization types across public-sector, higher education, nonprofit, for-profit, tribal, and other categories, including non-U.S. (foreign) entities.
Which public-sector organizations are eligible?
Eligible public-sector applicants may include state, county, and city or township governments; special district governments; independent school districts; and public housing authorities/Indian housing authorities.
Are colleges and universities eligible to apply?
Yes. Higher education institutions are eligible, including public and state-controlled institutions of higher education as well as private institutions of higher education.
Are tribal entities eligible?
Yes. The opportunity explicitly includes federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized governments.
Are specific institution types like HBCUs and Hispanic-serving Institutions eligible?
Yes. The opportunity highlights eligibility for Tribally Controlled Colleges and Universities (TCCUs), Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI).
Can faith-based or community-based organizations apply?
Yes. Faith-based or community-based organizations are listed as eligible.
Are federal agencies eligible applicants?
Yes. Eligible federal agencies are included among eligible applicant types.
Are regional organizations eligible?
Yes. Regional organizations are listed as eligible.
Can organizations in U.S. territories or possessions apply?
Yes. Applicants located in a U.S. territory or possession are included as eligible.
Are nonprofit organizations eligible if they do not have 501(c)(3) status?
Yes. Nonprofit organizations are eligible whether or not they have 501(c)(3) status.
Are for-profit organizations eligible?
Yes. For-profit organizations are eligible, including small businesses and other for-profit entities that are not small businesses.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-domestic (non-U.S.) entities (foreign organizations) are included as eligible applicants, which may support clinical trial questions requiring international settings or populations, provided the work fits NICHD priorities and complies with NIH policies.
When was this opportunity created?
The opportunity was created on 2024-11-18.
What is the listed closing date for this opportunity?
The original closing date is listed as 2028-01-07, indicating a multi-year open period typical of NIH program announcements with recurring submission cycles.
Does the information provided specify the number of awards expected?
No. The summary data provided does not specify the number of expected awards.
What does the long open period suggest about submission opportunities?
The long open window suggests ongoing opportunities for submission across multiple receipt dates, consistent with NIH program announcements that recur over time.
What is the overall purpose of this program in practical terms?
It provides a targeted route for teams with a clinical trial concept within NICHD's scientific scope to run a smaller trial that tests an approach, establishes feasibility, collects early efficacy signals, or otherwise builds evidence that can justify a subsequent, larger-scale study.
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Apply for PA 25 125
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