Opportunity Information: Apply for PA 21 195
The Mentored Career Transition Award for Intramural Fellows (K22 Clinical Trials Required), funding opportunity number PA-21-195, is an NIH grant program run by the National Institute of Mental Health (NIMH) to help NIMH Division of Intramural Research Programs (DIRP) postdoctoral fellows move from an intramural postdoc position into an extramural, independent faculty role. It is a reissue of an earlier announcement (PA-18-613) and is structured specifically to support a timely, well-planned transition into a tenure-track or equivalent position at an eligible US institution, while keeping strong mentorship in place during both stages of the move.
This K22 is organized as a two-phase career development pathway. The first phase takes place while the applicant is still an intramural fellow within NIMH DIRP, where the candidate continues mentored development and prepares for independence. The second phase begins after the awardee secures an eligible extramural faculty appointment, at which point the award provides research support intended to help the investigator establish and launch an independent research program. The overall aim is to bridge a common career gap: the period when a promising postdoc is ready to lead a research direction but needs protected support, mentoring, and resources to become competitive as an independent investigator.
A defining feature of this specific FOA is its clinical trial requirement. It is meant for applicants who will serve as the lead investigator of an independent clinical trial. That includes three main possibilities: (1) a full independent clinical trial, (2) a clinical trial feasibility study that tests whether a larger trial is workable, or (3) an ancillary study that is separate but tied to an existing clinical trial (for example, collecting additional measures or addressing a related mechanistic question alongside an ongoing trial). In other words, the proposed research and career development plan must involve the applicant taking primary responsibility for designing and directing a clinical trial component, rather than only participating in someone else’s trial. If an applicant is not planning to lead an independent trial, or if they are seeking clinical trial experience under another investigator’s leadership, they are directed to apply to the companion announcement referenced in the text (PA-18-NNN) instead of this “Clinical Trials Required” version.
In terms of who can apply and where the work can be done, the program is oriented to US-based institutions and positions. Eligible applicant organizations include a wide range of entities such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits), for-profit organizations (other than small businesses), small businesses, and other eligible organizations. The FOA also explicitly highlights institutional categories that may apply, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and eligible agencies of the federal government. At the same time, it clearly states that non-US entities are not eligible to apply, non-US components of US organizations are not eligible, and foreign components are not allowed under NIH policy definitions, reinforcing that the transition target and funded activities must remain within allowable US-based settings.
Administratively, this opportunity is categorized as a discretionary grant in the health area, with CFDA number 93.242. The posted information lists an original closing date of 2023-04-20 and a creation date of 2021-03-16. The award ceiling and expected number of awards are not specified in the provided source data, which typically means applicants need to consult the full FOA text and NIH budget guidance for the most current financial and policy details. Overall, the program is best understood as a mentored, two-stage launchpad for NIMH intramural postdoctoral fellows who are ready to step into an extramural faculty role and who will build their early independent research trajectory around leading a clinical trial or closely related trial-focused study.Apply for PA 21 195
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mentored Career Transition Award for Intramural Fellows (K22 Clinical Trials Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
- This funding opportunity was created on 2021-03-16.
- Applicants must submit their applications by 2023-04-20. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Mentored Career Transition Award for Intramural Fellows (K22 Clinical Trials Required)?
This opportunity (funding opportunity number PA-21-195) is an NIH career development grant run by the National Institute of Mental Health (NIMH). It is designed to help NIMH Division of Intramural Research Programs (DIRP) postdoctoral fellows transition from an intramural postdoctoral fellowship into an extramural, independent faculty position, while maintaining strong mentorship during the transition.
Who is the sponsoring NIH institute for this K22?
The program is administered by the National Institute of Mental Health (NIMH).
What career stage is this K22 intended to support?
It is specifically aimed at NIMH DIRP postdoctoral fellows who are preparing to move from an intramural postdoc role into an extramural independent faculty role (tenure-track or equivalent) at an eligible U.S. institution.
What is the main purpose of this award?
The award is meant to bridge a common career gap: the period when a postdoctoral fellow is ready to lead an independent research direction but still benefits from protected support, structured mentoring, and resources to become competitive as an independent investigator in an extramural faculty role.
How is the K22 structured?
This K22 is a two-phase career development pathway. Phase 1 occurs while the candidate remains an intramural fellow in the NIMH DIRP. Phase 2 begins after the awardee secures an eligible extramural faculty appointment, at which point the award supports launching an independent research program.
What happens during Phase 1?
Phase 1 takes place while the applicant is still an intramural postdoctoral fellow within NIMH DIRP. The candidate continues mentored career development and prepares for independence, with an emphasis on a timely and well-planned transition.
What triggers the start of Phase 2?
Phase 2 begins after the awardee secures an eligible extramural faculty appointment (tenure-track or equivalent) at an eligible U.S. institution.
What does Phase 2 support?
Phase 2 provides research support intended to help the investigator establish and launch an independent research program in the extramural setting.
Does this FOA require clinical trials?
Yes. A defining feature of PA-21-195 is that clinical trials are required. The proposed research and career development plan must involve the applicant serving as the lead investigator of an independent clinical trial component.
What kinds of clinical trial activities are acceptable under this FOA?
The FOA describes three main possibilities that meet the clinical trial requirement: (1) a full independent clinical trial, (2) a clinical trial feasibility study to determine whether a larger trial is workable, or (3) an ancillary study that is separate but tied to an existing clinical trial (for example, collecting additional measures or pursuing a related mechanistic question alongside an ongoing trial).
What does it mean to be the “lead investigator” for the required clinical trial?
Based on the description provided, it means the applicant takes primary responsibility for designing and directing the clinical trial component, rather than simply participating in a clinical trial led by another investigator.
Can someone apply if they only want clinical trial experience under another investigator’s leadership?
No. Applicants who are seeking clinical trial experience while working under another investigator’s clinical trial leadership are directed to apply to the companion announcement referenced in the description (PA-18-NNN), not this “Clinical Trials Required” FOA.
Is this FOA a new opportunity or a reissue?
It is described as a reissue of an earlier announcement (PA-18-613).
What types of organizations are eligible to apply?
The eligible applicant organizations listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits), for-profit organizations (other than small businesses), small businesses, and other eligible organizations.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA explicitly highlights categories that may apply, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are federal government agencies eligible to apply?
Yes. The description states that eligible agencies of the federal government are included among the institutional categories that may apply.
Are non-U.S. entities eligible to apply?
No. The description states that non-U.S. entities are not eligible to apply.
Can a U.S. organization include non-U.S. components or foreign components in this application?
No. The description states that non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed under NIH policy definitions.
Where is the intended career transition expected to occur?
The program is oriented to U.S.-based institutions and positions, with Phase 2 beginning after the awardee obtains an eligible extramural faculty appointment at an eligible U.S. institution.
What is the CFDA number associated with this opportunity?
The CFDA number listed for this opportunity is 93.242.
How is this opportunity categorized administratively?
It is categorized as a discretionary grant in the health area.
What are the posted dates for this opportunity?
The source information lists a creation date of 2021-03-16 and an original closing date of 2023-04-20.
What is the award ceiling for this grant?
The award ceiling is not specified in the provided information.
How many awards are expected to be made?
The expected number of awards is not specified in the provided information.
What should applicants do if budget or award count details are not listed?
Because the award ceiling and expected number of awards are not specified in the provided source data, applicants are typically expected to consult the full FOA text and NIH budget guidance for the most current financial and policy details.
In one sentence, who is this K22 best suited for?
This K22 is best suited for NIMH DIRP intramural postdoctoral fellows who are ready to transition to an extramural tenure-track (or equivalent) faculty role and who will lead an independent clinical trial, feasibility trial study, or ancillary trial-related study as part of their early independent research trajectory.
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