Opportunity Information: Apply for RFA PS 21 003
PrEP Choice: Increasing the Use of HIV Pre-exposure Prophylaxis in an Era of Choices (Funding Opportunity Number RFA PS 21 003) is a CDC cooperative agreement designed to boost real-world uptake and effective use of HIV pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) at a time when multiple PrEP options are available. The program focuses on what happens inside clinical settings, aiming to strengthen how providers and clinics identify patients who may benefit from PrEP, counsel them, start them on PrEP, and then support them to stay on PrEP with good adherence and long-term persistence. A key theme is moving beyond simple awareness and into practical, clinic-embedded workflows and tools that lead to measurable increases in PrEP delivery and continuity of care.
The opportunity has two main goals. First, recipients are expected to implement evidence-based education and support tools for both providers and patients in clinical settings. On the provider side, this includes a structured education module and related supports that help clinicians and clinic staff consistently screen for PrEP indications, have high-quality PrEP conversations, and reduce missed opportunities for PrEP initiation. On the patient side, it includes tools that support informed decision-making, initiation, and continued use. The overall intent is to make PrEP discussion and offering more routine and systematic, rather than dependent on individual provider comfort or patient self-advocacy.
Second, the project is meant to generate a clearer picture of how MSM use PrEP in everyday practice when there are multiple formulation choices. Recipients will collect data to understand which PrEP formulation people choose, why they choose it, and how they move between options over time. The NOFO specifically calls out daily PrEP, 2-1-1 PrEP (an event-driven dosing approach), and injectable PrEP, with an emphasis on describing selection factors and switching patterns. In practical terms, this means tracking not only initiation but also how preferences, life circumstances, side effects, access barriers, clinic processes, and patient experiences may influence whether someone stays with a regimen, changes regimens, or stops and later restarts.
A defining feature of the funding is its implementation science approach. Rather than only delivering services, recipients are expected to evaluate how well the provider education module and support tools work in real clinics, using implementation science methods to assess effectiveness and produce usable lessons about what improves PrEP screening, counseling, uptake, adherence, and persistence. This typically implies careful measurement of outcomes and processes in routine care settings, attention to how the intervention is adopted by staff, and an effort to understand practical facilitators and barriers that affect success. The end product is not just increased PrEP use in participating clinics, but evidence about how and why the approach works so it can be replicated or scaled.
Administratively, this is a discretionary funding opportunity from the Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), using a cooperative agreement mechanism, which generally indicates substantial federal involvement or collaboration during the project period compared with a standard grant. The funding activity category is Health, and the CFDA numbers listed are 93.941 and 93.943. The opportunity was created on October 23, 2020, with an original application closing date of January 5, 2021 (applications due by 5:00 p.m. ET). The expected number of awards was six, with an award ceiling of $1,040,000.
Eligibility is broad and includes many common public and private entities that operate or partner with clinical systems and HIV prevention programs. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. This wide eligibility reflects the reality that PrEP delivery and evaluation can be housed in health departments, academic medical centers, community health networks, community-based organizations, and other clinical or public health partnerships.
Overall, the grant is centered on improving the quality and consistency of PrEP delivery in clinical care for MSM while simultaneously documenting how people choose among daily, event-driven, and injectable PrEP options and how they switch between them. The intent is to pair practical clinic improvement work with rigorous evaluation, producing both near-term gains in PrEP engagement and durable evidence to guide HIV prevention strategy in an evolving PrEP landscape.Apply for RFA PS 21 003
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "PrEP Choice: Increasing the Use of HIV Pre-exposure Prophylaxis in an Era of Choices" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.941, 93.943.
- This funding opportunity was created on Oct 23, 2020.
- Applicants must submit their applications by Jan 05, 2021 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,040,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses.
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