Opportunity Information: Apply for RFA PS 21 003
PrEP Choice: Increasing the Use of HIV Pre-exposure Prophylaxis in an Era of Choices (Funding Opportunity Number RFA PS 21 003) is a CDC cooperative agreement designed to boost real-world uptake and effective use of HIV pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) at a time when multiple PrEP options are available. The program focuses on what happens inside clinical settings, aiming to strengthen how providers and clinics identify patients who may benefit from PrEP, counsel them, start them on PrEP, and then support them to stay on PrEP with good adherence and long-term persistence. A key theme is moving beyond simple awareness and into practical, clinic-embedded workflows and tools that lead to measurable increases in PrEP delivery and continuity of care.
The opportunity has two main goals. First, recipients are expected to implement evidence-based education and support tools for both providers and patients in clinical settings. On the provider side, this includes a structured education module and related supports that help clinicians and clinic staff consistently screen for PrEP indications, have high-quality PrEP conversations, and reduce missed opportunities for PrEP initiation. On the patient side, it includes tools that support informed decision-making, initiation, and continued use. The overall intent is to make PrEP discussion and offering more routine and systematic, rather than dependent on individual provider comfort or patient self-advocacy.
Second, the project is meant to generate a clearer picture of how MSM use PrEP in everyday practice when there are multiple formulation choices. Recipients will collect data to understand which PrEP formulation people choose, why they choose it, and how they move between options over time. The NOFO specifically calls out daily PrEP, 2-1-1 PrEP (an event-driven dosing approach), and injectable PrEP, with an emphasis on describing selection factors and switching patterns. In practical terms, this means tracking not only initiation but also how preferences, life circumstances, side effects, access barriers, clinic processes, and patient experiences may influence whether someone stays with a regimen, changes regimens, or stops and later restarts.
A defining feature of the funding is its implementation science approach. Rather than only delivering services, recipients are expected to evaluate how well the provider education module and support tools work in real clinics, using implementation science methods to assess effectiveness and produce usable lessons about what improves PrEP screening, counseling, uptake, adherence, and persistence. This typically implies careful measurement of outcomes and processes in routine care settings, attention to how the intervention is adopted by staff, and an effort to understand practical facilitators and barriers that affect success. The end product is not just increased PrEP use in participating clinics, but evidence about how and why the approach works so it can be replicated or scaled.
Administratively, this is a discretionary funding opportunity from the Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), using a cooperative agreement mechanism, which generally indicates substantial federal involvement or collaboration during the project period compared with a standard grant. The funding activity category is Health, and the CFDA numbers listed are 93.941 and 93.943. The opportunity was created on October 23, 2020, with an original application closing date of January 5, 2021 (applications due by 5:00 p.m. ET). The expected number of awards was six, with an award ceiling of $1,040,000.
Eligibility is broad and includes many common public and private entities that operate or partner with clinical systems and HIV prevention programs. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. This wide eligibility reflects the reality that PrEP delivery and evaluation can be housed in health departments, academic medical centers, community health networks, community-based organizations, and other clinical or public health partnerships.
Overall, the grant is centered on improving the quality and consistency of PrEP delivery in clinical care for MSM while simultaneously documenting how people choose among daily, event-driven, and injectable PrEP options and how they switch between them. The intent is to pair practical clinic improvement work with rigorous evaluation, producing both near-term gains in PrEP engagement and durable evidence to guide HIV prevention strategy in an evolving PrEP landscape.Apply for RFA PS 21 003
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "PrEP Choice: Increasing the Use of HIV Pre-exposure Prophylaxis in an Era of Choices" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.941, 93.943.
- This funding opportunity was created on Oct 23, 2020.
- Applicants must submit their applications by Jan 05, 2021 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,040,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the PrEP Choice funding opportunity (RFA PS 21 003)?
PrEP Choice: Increasing the Use of HIV Pre-exposure Prophylaxis in an Era of Choices (Funding Opportunity Number RFA PS 21 003) is a CDC discretionary cooperative agreement focused on increasing real-world uptake and effective use of HIV pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) in clinical settings, especially as multiple PrEP options are available.
Which federal agency is offering this opportunity?
This opportunity is offered by the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC).
What type of funding mechanism is used?
The mechanism is a cooperative agreement, which generally indicates substantial federal involvement or collaboration during the project period compared with a standard grant.
What is the main purpose of the program?
The program is designed to improve the quality, consistency, and outcomes of PrEP delivery inside clinical settings. It emphasizes practical, clinic-embedded workflows and tools that lead to measurable increases in PrEP identification, counseling, initiation, adherence, and long-term persistence.
Who is the primary population focus for this program?
The primary focus is on men who have sex with men (MSM), with the goal of boosting PrEP uptake and effective use in real-world clinical practice.
What settings does the project focus on?
The project focuses on what happens inside clinical settings, including how clinics and providers identify patients who may benefit from PrEP, counsel them, start PrEP, and support continued use with good adherence and long-term persistence.
What are the two main goals of the opportunity?
The two main goals are: (1) implement evidence-based education and support tools for providers and patients in clinical settings, and (2) collect data to better understand how MSM choose and use different PrEP formulations over time, including switching patterns and reasons for those choices.
What kinds of provider-focused activities are expected?
Recipients are expected to implement a structured provider education module and related supports to help clinicians and clinic staff consistently screen for PrEP indications, conduct higher-quality PrEP conversations, and reduce missed opportunities for PrEP initiation.
What kinds of patient-focused tools or supports are expected?
Recipients are expected to implement evidence-based tools that support patient informed decision-making about PrEP options, support PrEP initiation, and help patients stay on PrEP with good adherence and long-term persistence.
How does the program aim to change PrEP delivery in clinics?
The program aims to make PrEP discussion and offering more routine and systematic by embedding workflows and tools into clinic processes, rather than relying on individual provider comfort or patient self-advocacy.
Which PrEP options are specifically referenced in the NOFO description?
The opportunity specifically calls out daily PrEP, 2-1-1 PrEP (an event-driven dosing approach), and injectable PrEP, with an emphasis on understanding how people select among options and switch between them over time.
What kinds of data are recipients expected to collect?
Recipients are expected to collect data that describe which PrEP formulation MSM choose, why they choose it, and how they move between PrEP options over time. This includes documenting selection factors and switching patterns in everyday practice.
What factors may be examined to explain PrEP choice and switching?
The description notes that switching and persistence may be influenced by preferences, life circumstances, side effects, access barriers, clinic processes, and patient experiences, and recipients are expected to help clarify how such factors relate to regimen choice, switching, stopping, and restarting.
What does it mean that this opportunity uses an implementation science approach?
It means recipients are expected not only to implement tools and supports in real clinics, but also to evaluate how well those approaches work in routine care using implementation science methods. The goal is to produce usable lessons about what improves PrEP screening, counseling, uptake, adherence, and persistence, including practical facilitators and barriers to success.
What is the intended end product of the funded work?
The intended end product includes (1) increased PrEP engagement and continuity of care in participating clinics and (2) evidence about how and why the approach works so it can be replicated or scaled in other settings.
What is the funding activity category?
The funding activity category is Health.
What CFDA numbers are associated with this opportunity?
The CFDA numbers listed are 93.941 and 93.943.
When was the opportunity created?
The opportunity was created on October 23, 2020.
What was the original application closing date and time?
The original application closing date was January 5, 2021, with applications due by 5:00 p.m. ET.
How many awards were expected?
The expected number of awards was six.
What was the award ceiling?
The award ceiling was $1,040,000.
Who is eligible to apply?
Eligibility is broad and includes: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Why is eligibility so broad for this opportunity?
The eligibility is broad because PrEP delivery and evaluation can be housed in many types of entities and partnerships, including health departments, academic medical centers, community health networks, community-based organizations, and other clinical or public health collaborations.
Is this opportunity focused only on awareness campaigns about PrEP?
No. A key theme is moving beyond simple awareness and into practical, clinic-embedded workflows and tools that lead to measurable increases in PrEP delivery and continuity of care.
Does the opportunity emphasize initiation only, or also staying on PrEP?
It emphasizes both. The program focuses on identifying candidates and starting PrEP, and also supporting adherence and long-term persistence, including understanding why people may switch regimens, stop, or later restart.
What does "reducing missed opportunities for PrEP initiation" mean in this context?
In this context, it refers to improving clinical screening and counseling processes so that patients who may benefit from PrEP are more consistently identified and offered PrEP through routine, systematic clinic workflows.
What is meant by "real-world uptake and effective use" of PrEP?
It refers to increasing PrEP use in everyday clinical practice (not just in research settings), and ensuring that use is supported through counseling, initiation support, adherence support, and longer-term persistence.
Browse more opportunities from the same category: Health
Next opportunity: Head Start/Early Head Start Grantee -- Communities in the state of Alabama
Previous opportunity: SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM (SCSEP) GRANTEES
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA PS 21 003
Applicants also applied for:
Applicants who have applied for this opportunity (RFA PS 21 003) also looked into and applied for these:
| Funding Opportunity |
|---|
| National Telehealth Resource Center Program Apply for HRSA 21 023 Funding Number: HRSA 21 023 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $325,000 |
| Regional Telehealth Resource Center Program Apply for HRSA 21 022 Funding Number: HRSA 21 022 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $325,000 |
| Maternal Child Health (MCH) Research Network on Promoting Healthy Weight among Children with Autism Spectrum Disorder and other Developmental Disabilities Apply for HRSA 21 038 Funding Number: HRSA 21 038 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Advancing Public Health Research in Kenya Apply for RFA GH 21 003 Funding Number: RFA GH 21 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $15,000,000 |
| UT5 Developmental Behavioral Pediatrics Research Network (DBPNet) Apply for HRSA 21 039 Funding Number: HRSA 21 039 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $275,000 |
| Characterizing the Natural History of Fragile X Syndrome to Inform the Development of Intervention Outcome Measures Apply for RFA DD 21 002 Funding Number: RFA DD 21 002 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $800,000 |
| Statewide Family Network Apply for SM 21 002 Funding Number: SM 21 002 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $950,000 |
| Statewide Consumer Network Program Apply for SM 21 001 Funding Number: SM 21 001 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $95,000 |
| Grants to Support States in Providing Added Flexibility to Strengthen the Private Health Insurance Market through Implementation of Market Reforms under Part A of Title XXVII of the Public Health Service Act, Apply for PR PRP 21 001 Funding Number: PR PRP 21 001 Agency: Department of Health and Human Services, CMS-Consumer Information Insurance Oversight Category: Health Funding Amount: $23,700,000 |
| Ryan White HIV/AIDS Program Part D -- Women, Infants, Children, and Youth (WICY) Grants Supplemental Funding Apply for HRSA 21 059 Funding Number: HRSA 21 059 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Conducting Research to Inform Pandemic Response and Recovery of Emergency-Affected Populations by Determining Public Health Needs, Improving Methods, and Integrating Services to Mitigate Morbidity and Mortality Apply for RFA GH 21 004 Funding Number: RFA GH 21 004 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $3,000,000 |
| Implementation Research Consortium to Accelerate Impact of Health Department-Delivered HIV Prevention Activities Apply for RFA PS 21 002 Funding Number: RFA PS 21 002 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $1,150,000 |
| Client-Oriented Response for HIV Epidemic Control (CORE) Activity Apply for 72061220RFA00015 Funding Number: 72061220RFA00015 Agency: Agency for International Development, Malawi USAID-Lilongwe Category: Health Funding Amount: $80,000,000 |
| Epidemiologic Cohort Study of Interstitial Cystitis Apply for RFA DP 21 002 Funding Number: RFA DP 21 002 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $900,000 |
| Conducting Public Health Research in Thailand: Technical collaboration with the Ministry of Public Health (MOPH) in the Kingdom of Thailand Apply for RFA GH 21 001 Funding Number: RFA GH 21 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $7,000,000 |
| Conducting Public Health Research in Ethiopia Apply for RFA GH 21 005 Funding Number: RFA GH 21 005 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $250,000 |
| Strengthening Public Health Research and Implementation Science (Operations Research) to Control and Eliminate Infectious Diseases Globally Apply for RFA GH 21 006 Funding Number: RFA GH 21 006 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $2,000,000 |
| Building Capacity to Improve Collecting and Reporting Viral Suppression Data to the Medicaid Adult Core Set Apply for HRSA 21 083 Funding Number: HRSA 21 083 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $4,000,000 |
| Leadership Education in Neurodevelopmental and Other Related Disabilities (LEND) Apply for HRSA 21 041 Funding Number: HRSA 21 041 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Promoting the Importance of Infant and Childhood Vaccination Among Pregnant Women by Prenatal Care Providers Apply for RFA IP 21 001 Funding Number: RFA IP 21 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $500,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA PS 21 003", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.