Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trial Optional) | RFA CA 23 010

Opportunity Information: Apply for RFA CA 23 010

The grant opportunity "Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trial Optional)" (RFA-CA-23-010) is a discretionary NIH funding announcement from the National Cancer Institute (NCI) focused specifically on revision applications to existing NCI-funded P50 Specialized Center awards. In practical terms, it is not meant for brand-new P50 centers or brand-new standalone projects. Instead, it targets organizations that already hold an active NCI P50 award and want to submit a competitive revision (now referred to as a "revision application") to strengthen or extend the currently funded center by adding a new technology component.

The central goal is to speed up cancer research progress within the parent P50 by incorporating a novel technical approach, platform, or instrument that was developed with support from NCI's Innovative Molecular Analysis Technologies (IMAT) program. Applicants are expected to use these IMAT-supported technologies to either expand the original research questions from one or more specific projects within the P50 center or to accelerate the overall progress of the parent study. The emphasis is on meaningful integration of emerging technology in a way that pushes the science forward faster than the original plan could on its own, rather than simply adding minor enhancements or routine upgrades.

A key intent behind the awards is to incentivize independent validation of emerging IMAT technologies and to accelerate their readiness and suitability for broader use by the appropriate research communities. That means the revisions should do more than just "try out" a tool; they should help demonstrate performance, reliability, applicability, and real-world utility in the context of cancer research. The FOA sits within the broader IMAT mission, which is to promote interdisciplinary collaboration and the development and adoption of innovative tools and methods that enable cancer research and accelerate scientific discovery. In other words, the NCI is using this mechanism to help promising new technologies cross the gap from development into impactful, scientifically rigorous use inside established cancer research centers.

The FOA uses the grant funding instrument and is categorized under education and health activities, associated with CFDA (Assistance Listing) number 93.394. Clinical trials are optional under this announcement, meaning a proposed revision may include a clinical trial component if it is appropriate for the P50 center's work and consistent with NIH and NCI requirements, but a clinical trial is not required to apply.

Eligibility is broad in the general NIH sense, but the defining eligibility feature is that applicants must be currently funded NCI P50 specialized centers seeking revisions to their active awards. Within that constraint, the eligible applicant types listed include a wide range of domestic organizations and governmental units, such as state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses) and small businesses; and other entities. The announcement also explicitly highlights inclusion of organizations such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, U.S. territories or possessions, and even non-U.S. (foreign) entities, indicating a wide net for participation where consistent with NIH policy and the P50 revision requirement.

The opportunity was created on 2022-12-02 and listed an original closing date of 2023-09-01. The source information provided does not specify an award ceiling or the expected number of awards, which typically means applicants would need to consult the full FOA text or NIH notices for budget limits, scope expectations, and review considerations. Overall, the program is best understood as a targeted add-on funding pathway for existing NCI P50 centers to rapidly incorporate and independently validate cutting-edge IMAT-developed technologies in order to accelerate cancer research outputs and broaden the usefulness of those technologies to the wider research community.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394.
• This funding opportunity was created on 2022-12-02.
• Applicants must submit their applications by 2023-09-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 23 010

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