Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed) | PAR 23 075

Opportunity Information: Apply for PAR 23 075

The National Institutes of Health (NIH), through the NIH Common Fund, is offering an R03 small grant opportunity titled "Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed)" under funding opportunity number PAR-23-075. This program sits within the Gabriella Miller Kids First Pediatric Research Program (Kids First), which was created to build and expand a high-value pediatric research data resource containing genomic sequence data and linked phenotypic information. The core purpose is to make it easier for researchers to study the genetic and biological factors behind childhood cancers and structural birth defects by providing curated datasets and a central portal where the research community can access both the data and relevant analysis tools.

This funding opportunity is specifically aimed at supporting small, focused research projects that analyze genomic datasets generated by the Kids First program and/or associated phenotypic datasets connected to those cohorts. The emphasis is on using the existing Kids First Data Resource to ask well-defined scientific questions that can be addressed with relatively limited scope and budget, consistent with the R03 mechanism. In addition to direct analyses of the available genomic and phenotypic data, applicants may also propose the development of methods, tools, or algorithms that are well-suited for analyzing genomic, phenotypic, and/or clinical data relevant to Kids First. In practical terms, that means projects might include things like innovative analytic pipelines for rare disease gene discovery, approaches for harmonizing phenotype data across cohorts, strategies for integrative analysis that links genotype to pediatric outcomes, or computational methods that improve interpretation of variants in the context of childhood cancer or birth defects.

The opportunity is explicitly marked "Clinical Trial Not Allowed," which means the work should be based on data analysis, tool development, and related computational or informatics efforts rather than proposing prospective clinical interventions or trials. The long-term vision behind Kids First, and by extension this grant, is to encourage comprehensive and cross-cutting research that accelerates collaboration, strengthens diagnostic precision, and supports the eventual development of more targeted therapies and interventions for pediatric conditions. By lowering the barrier to entry with a small-grant format, the NIH is encouraging teams to explore promising ideas, test novel hypotheses, and build reusable analytic approaches that can benefit a broad community of investigators working with pediatric genomic and phenotypic datasets.

Eligibility for this grant is broad and includes many types of U.S.-based organizations and government entities, such as state, county, city or township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; and a wide range of nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities that are not institutions of higher education). For-profit organizations (other than small businesses) and small businesses are also eligible, along with federally recognized Native American tribal governments and other Native American tribal organizations. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, eligible federal agencies, and even non-U.S. (foreign) organizations, reflecting an intent to broaden participation and maximize the scientific use of the Kids First resource.

Administratively, this is a discretionary NIH grant opportunity within health-related federal assistance programs and is associated with CFDA numbers 93.121, 93.394, 93.395, 93.396, and 93.865. The listed original closing date is 2026-01-07, and the opportunity record indicates it was created on 2022-12-23. While the source information provided does not specify an award ceiling or the expected number of awards, the overall structure and intent are consistent with an NIH R03: smaller, well-scoped projects designed to generate impactful results through targeted analyses or method development using the Kids First pediatric genomics and phenotype data ecosystem.

• The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.394, 93.395, 93.396, 93.865.
• This funding opportunity was created on 2022-12-23.
• Applicants must submit their applications by 2026-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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